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Several mechanisms may explain reduced effectiveness over time

Conclusively, our study could develop PEO-CS/PLGA core-shell nanofibers loaded with QS and LEV as a promising wound healing material and validate its therapeutic potentials in vivo

To encourage the approval of SPIGFD treatments around the world, there is an unmet need to improve the understanding of SPIGFD epidemiology and treatment response, particularly in regions where SPIGFD is less well-characterized

A key mechanism is the downregulation of MHC-I molecules mediated by the viral protein E5, which retains MHC-I within the Golgi and endoplasmic reticulum, reducing antigen presentation to CD8 + T cells and facilitating persistent infection (Miyauchi et al., 2023)